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. Author manuscript; available in PMC: 2011 Feb 1.

Published in final edited form as: Eur J Nucl Med Mol Imaging. 2009 Nov 17;37(2):339–348. doi: 10.1007/s00259-009-1310-y

Fig. 3 — Comparison of intratumoral distribution of ¹³¹I-IAZGP uptake, pimonidazole binding, CAIX expression, and blood perfusion in a microscopic and a larger HT29 intradermal (i.d.) tumor. The microscopic tumor (a) shows high ¹³¹I-IAZGP uptake, pimonidazole binding, and CAIX expression with little to no blood perfusion. The larger tumor (b) shows the complete opposite in all respects. Scale bar=500μm. The histogram (b) shows a summary of quantitative ¹³¹I-IAZGP uptake in 11 HT29 i.d. tumors from a variety of animals. ¹³¹I-IAZGP uptake was significantly higher in microscopic i.d. tumors (<1 mm diameter, n=5) than larger ones (>1 mm, n=6), p<0.001

Fig. 3 — Comparison of intratumoral distribution of ¹³¹I-IAZGP uptake, pimonidazole binding, CAIX expression, and blood perfusion in a microscopic and a larger HT29 intradermal (i.d.) tumor. The microscopic tumor (a) shows high ¹³¹I-IAZGP uptake, pimonidazole binding, and CAIX expression with little to no blood perfusion. The larger tumor (b) shows the complete opposite in all respects. Scale bar=500μm. The histogram (b) shows a summary of quantitative ¹³¹I-IAZGP uptake in 11 HT29 i.d. tumors from a variety of animals. ¹³¹I-IAZGP uptake was significantly higher in microscopic i.d. tumors (<1 mm diameter, n=5) than larger ones (>1 mm, n=6), p<0.001