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. Author manuscript; available in PMC: 2012 Sep 1.

Published in final edited form as: Neurobiol Aging. 2009 Oct 29;32(9):1716–1724. doi: 10.1016/j.neurobiolaging.2009.09.009

As young adults, the CBA has robust efferent feedback activation, particularly at low frequencies, the F1 has less response, and the C57 exhibits very little efferent activity. A) For young adults, the F1 is intermediate between the parental strains. CBA data re-plotted from Jacobson et al. (2003). The strain main effect was statistically significant: F=64.8, df=2, p<0.0001. B) The CBA continues to show more CS than the F1 in middle age, across the entire mouse hearing range. The strain main effect was statistically significant: F=27.7, df=1, p<0.0001. C) In old age, none of the strains show any significant CS efferent feedback system response.

As young adults, the CBA has robust efferent feedback activation, particularly at low frequencies, the F1 has less response, and the C57 exhibits very little efferent activity. A) For young adults, the F1 is intermediate between the parental strains. CBA data re-plotted from Jacobson et al. (2003). The strain main effect was statistically significant: F=64.8, df=2, p<0.0001. B) The CBA continues to show more CS than the F1 in middle age, across the entire mouse hearing range. The strain main effect was statistically significant: F=27.7, df=1, p<0.0001. C) In old age, none of the strains show any significant CS efferent feedback system response.