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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Neurotoxicology. 2009 Dec 5;31(5):562–571. doi: 10.1016/j.neuro.2009.12.002

Figure 4.

Figure 4

Effects of A) acute WIN 55212-2 and B) repeated WIN 55212-2 exposures on acute paraoxon toxicity. Rats were treated with paraoxon (0.4 mg/kg, sc) either just before a single dose of WIN (1.5 mg/kg, ip) or 2 hours after the seventh daily dose of WIN. Functional signs of toxicity (involuntary movements, tremors) were scored (1 = normal; 2 = slight tremors in neck and head; 3 = moderate tremors involving more caudal aspects of body; 4 = severe whole body tremors) by a blinded observer from 0.5–4 hours after paraoxon challenge. Data represent median ± interquartile range. No signs of toxicity were noted in rats receiving vehicles or WIN only (data not shown). An asterisk indicates a significant difference between groups. Data are modified from [129].