Table 2.
Abbreviations for the pharmacokinetic parameters
AUC extrapolated | percent of the AUC extrapolated to infinity |
AUCinf/Dose | the area under the curve from 0 to infinity per dose administered |
AUCinf | area under the curve from time 0 to infinity |
AUMCinf | area under the first moment curve from time 0 to infinity |
Cl/F | plasma clearance per fraction of the dose absorbed |
CMAX | maximum plasma concentration |
CMAX/Dose | maximum plasma concentration per dose administered |
T ½λz | terminal half-life |
λz | first-order rate constant |
MRTinf | mean residence time extrapolated to infinity |
TMAX | time to maximum plasma concentration |
Vz/F | apparent volume of distribution of the area fraction of the dose absorbed |
Relative F | relative fraction of the dose absorbed for each oral dose rate |