Table 3.
Pharmacokinetic parameters of oral gabapentin in Healthy Greyhound dogs
| 10 mg/kg targeted dose | 20 mg/kg targeted dose | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Geometric | Geometric | ||||||||
| Mean | Min | Median | Max | Mean | Min | Median | Max | ||
| Dose | mg/kg | 10.2 | 9.1 | 9.9 | 12.0 | 20.5 | 18.2 | 19.7 | 24.0 |
| Non-compartmental pharmacokinetic parameters | |||||||||
| AUC extrapolated | % | 4.00 | 0.92 | 5.98 | 11.17 | 3.08 | 0.56 | 4.52 | 10.32 |
| AUCinf/Dose | h*μg/mL | 4.77 | 3.92 | 4.81 | 5.61 | 4.21 | 3.00 | 4.22 | 6.29 |
| AUCinf | h*μg/mL | 48.77 | 39.77 | 49.50 | 63.02 | 86.02 | 60.00 | 83.01 | 151.24 |
| AUMCinf | h*h*μg/mL | 264.76 | 182.92 | 274.78 | 374.51 | 489.41 | 315.59 | 447.60 | 964.42 |
| Cl/F | mL/min/kg | 3.49 | 2.97 | 3.49 | 4.26 | 3.96 | 2.65 | 3.97 | 5.56 |
| CMAX | μg/mL | 8.54 | 5.32 | 9.68 | 10.90 | 13.22 | 10.70 | 12.95 | 18.20 |
| CMAX/Dose | μg/mL | 0.84 | 0.56 | 0.84 | 1.10 | 0.65 | 0.56 | 0.63 | 0.77 |
| T½λz | h | 3.25 | 2.63 | 3.35 | 3.68 | 3.41 | 3.07 | 3.39 | 3.91 |
| λz | 1/h | 0.213 | 0.189 | 0.207 | 0.263 | 0.203 | 0.177 | 0.205 | 0.226 |
| MRTinf | h | 5.43 | 4.60 | 5.40 | 6.78 | 5.69 | 5.01 | 5.40 | 6.94 |
| TMAX | h | 1.31 | 0.75 | 1.50 | 2.00 | 1.51 | 1.00 | 1.75 | 2.00 |
| Vz/F | L/kg | 0.983 | 0.850 | 0.942 | 1.256 | 1.170 | 0.835 | 1.207 | 1.476 |
| Relative F | 1.13 | 0.83 | 1.28 | 1.41 | N/A | N/A | N/A | N/A | |