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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: J Orthop Res. 2010 Sep;28(9):1220–1228. doi: 10.1002/jor.21103

Figure 5. Chronic compression induces increase in vascular sinus and cellularity in subchondral bone marrow.

Figure 5

Representative AB/OG histological sections (A–F) of the 8th and 9th caudal vertebrae from the 0X loaded (A,B) and 6X loaded (C–F) WT (A–D), and 6X loaded TNF-Tg (E,F) mice 8 weeks after implantation are shown at 10 X and 40 X magnifications. Of note is the ruptured annulus and hypertrophic nucleus pulposus of the herniated intervertebral disk in the 6X (C) vs. 0X (A) loaded WT, which occurs in the absence of detectable synovitis vs. TNF-Tg (E), synovitis indicated by arrows. Histomorphometry demonstrated that the 6X load significantly increased the vascular sinus space (G), and the cellularity (H), of WT marrow (*p<0.01).