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. Author manuscript; available in PMC: 2010 Jun 24.

Published in final edited form as: Gastroenterology. 2008 Apr 11;135(1):282–291.e1. doi: 10.1053/j.gastro.2008.04.004

Increased wt KLF6 expression with advanced stages of NAFLD. Either Total KLF6 mRNA isoforms (represented by black bars) or the wt isoform only (grey bars) have been quantified by semiquantitative TaqMan RT-PCR. The individual Brunt et al²⁵ histology scores and KLF6 RQ values are shown in Table 1, whereas the mean expression levels (RQ log) ± standard error within histologically defined grades of NAFLD are shown in this Figure (n = 31; P values are shown). (A) Stepwise increase in both Total KLF6 isoforms and wt KLF6 increased stepwise in association with increasing levels of inflammation (A). Although wt KLF6 also was increased significantly in association with advanced steatosis (B) and fibrosis (C), Total KLF6 isoforms were not. (A) ■, Total, P = .001; , wt, P = .010; (B) ■, P = .049; , P = .001; (C) ■, NS; , P = .03.

Inline graphic — Increased wt KLF6 expression with advanced stages of NAFLD. Either Total KLF6 mRNA isoforms (represented by black bars) or the wt isoform only (grey bars) have been quantified by semiquantitative TaqMan RT-PCR. The individual Brunt et al²⁵ histology scores and KLF6 RQ values are shown in Table 1, whereas the mean expression levels (RQ log) ± standard error within histologically defined grades of NAFLD are shown in this Figure (n = 31; P values are shown). (A) Stepwise increase in both Total KLF6 isoforms and wt KLF6 increased stepwise in association with increasing levels of inflammation (A). Although wt KLF6 also was increased significantly in association with advanced steatosis (B) and fibrosis (C), Total KLF6 isoforms were not. (A) ■, Total, P = .001; , wt, P = .010; (B) ■, P = .049; , P = .001; (C) ■, NS; , P = .03.