Table 3.
KLF6 Genotype Is Associated With the Fibrosis Score in NAFLD Patients: Clinical and Demographic Variables in the Combined Groups
| KLF6 IVS1-27G>A | KLF6 wt | P | |
|---|---|---|---|
| Number | 59 | 356 | |
| Sex (male) | 41 (69.5%) | 239 (67%) | .721 |
| Age, y | 47.76 ± 12.04 | 48.21 ± 12.78 | .729 |
| BMI, kg/m2 | 32.28 ± 5.45 | 32.20 ± 6.38 | .718 |
| Glucose level, mmol/L | 5.95 ± 2.16 | 6.38 ± 3.03 | .719 |
| Insulin level | 27.5 ± 21.2 | 22.0 ± 18.2 | .127 |
| Triglyceride level, mmol/L | 2.37 ± 1.47 | 2.42 ± 1.64 | .719 |
| Cholesterol level, mmol/L | 5.63 ± 1.54 | 5.49 ± 1.28 | .804 |
| HDL level, mmol/L | 1.21 ± 0.36 | 1.24 ± 0.36 | .702 |
| Total bilirubin level, μmol/L | 12.79 ± 8.07 | 13.36 ± 10.38 | .545 |
| ALT level | 77 ± 49 | 78 ± 61 | .520 |
| AST level | 53 ± 40 | 48 ± 32 | .656 |
| AST/ALT ratio | 0.71 ± 0.33 | 0.73 ± 0.37 | .624 |
| GGT level | 96 ± 94 | 120 ± 177 | .668 |
| Platelets, ×109 L | 239 ± 55 | 234 ± 74 | .680 |
| Hypertension | 27/53 (51%) | 138/326 (42%) | .241 |
| Diabetes | 19/58 (33%) | 105/348 (30%) | .693 |
| Fat score | .432 | ||
| 1 | 20 (34%) | 131 (38%) | |
| 2 | 30 (52%) | 119 (34%) | |
| 3 | 8 (14%) | 97 (28%) | |
| Inflammation | 38/58 (65%) | 232/348 (67%) | .864 |
| Fibrosis | .055 | ||
| 0 | 24 (41%) | 132 (37%) | |
| 1 | 19 (32%) | 56 (16%) | |
| 2 | 7 (12%) | 64 (18%) | |
| 3 | 5 (8%) | 63 (18%) | |
| 4 | 4 (7%) | 41 (11%) | |
| Fibrosis >2 | 16 (27%) | 168 (47%) | .004 |
| HCC | 1 (1.7%) | 3 (0.84%) | .535 |
GGT, γ-glutamyltransferase; HDL, high-density lipoprotein.