Figure 2.

S-nitrosylation of NSF is anti-inflammatory and anti-thrombotic⁷³, ⁷⁴. In endothelial cells, inhibitory S-nitrosylation of NSF suppresses exocytosis of Weibel-Palade bodies and thereby externalization of P-selectin, which inhibits leukocyte rolling and thus vascular inflammation. Similarly, in platelets (labeling in parentheses), inhibitory S-nitrosylation of NSF suppresses exocytosis of secretory granules and thereby externalization of P-selectin (and other adhesive molecules), which reduce platelet activation, adhesion, aggregation and rolling on the endothelium. These effects are anti-thrombotic.