Skip to main content
. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Hippocampus. 2010 Aug;20(8):980–993. doi: 10.1002/hipo.20697

Fig. 7.

Fig. 7

Elevation of synaptic glutamate concentration by application of glutamate transporter inhibitors increases sIPSC frequency recorded from principal neurons and induced an inward HC in layer III interneurons of the EC. A, Bath application of TBOA (100 μM), a neuronal and glial glutamate transporter inhibitor, significantly enhanced sIPSC frequency (p<0.001, two-way ANOVA). B, Pretreatment of slice with and continuous bath application of MPEP (10 μM), a mGluR5 inhibitor, blocked TBOA-induced increases in sIPSC frequency (p=0.81, two-way ANOVA). C, Bath application of DHK (200 μM), a glial glutamate transporter inhibitor, significantly increased sIPSC frequency (p=0.002, two-way ANOVA). D, Pretreatment of slices with and continuous bath application of MPEP (10 μM) blocked DHK-induced increases in sIPSC frequency (p=0.91, two-way ANOVA). E, Bath application of TBOA (100 μM) induced an inward HC in layer III interneurons of the EC (p<0.001, two-way ANOVA). F, Pretreatment of slices with and continuous bath application of MPEP (10 μM) blocked the effect of TBOA on HCs recorded from entorhinal interneurons (p=0.99, two-way ANOVA).