Figure 1.
Induction of different types of diabetes in middle age CBA/CaJ mice. A. Diabetes alters body weight: T1DM showed significant body weight loss, whereas T2DM showed significant body weight gain, with no changes in controls over the 6 month experimental timeframe. B. Diabetes elevates fasted glucose levels in middle aged CBA mice: T1DM showed significant elevation of fasted blood glucose level by 2 months, whereas T2DM showed significant elevation of fasted blood glucose by 4 months. The control group showed no changes. Differences were compared to baseline. Data presented as mean ± SEM. Asterisks indicate significant differences: * p < 0.05, ** p< 0.01, *** p<0.001. n, number of mice in each subject group.