Table 3.

Top-list ANOVA gene-score annotation for CE&P genes altered by ICM in atrial and ventricular myocytes as compared to healthy subjects

Gene	Genbank #	Variant accession #	p-Value* (ICM/H)	Gfold Change* (ICM/H)
Atrial myocytes
FXYD16,7	NM_021902	H75358	0.02859	2.3
CLIC18	NM_001288	BU173816	0.04412	1.6
CLIC48	NM_013943	BG436443	0.04047	1.6
KCNJ149,10	NM_013348	na	0.01289	−1.6†
FXYD7	NM_022006	CQ722304	0.01907	−1.6
CHRNA1011	NM_020402	CR744383	0.02780	−1.6
CACNG712	NM_031896	H19702	0.01039	−1.6
GRIA313	NM_000828	DA531074	0.01945	−1.7
KCND314	NM_004980	NM_172198	0.00837	−1.7
KCNK49,15	NM_016611	BE900958	0.01063	−1.8
SCN1B16–18	NM_001037	DA062026	0.03059	−1.8
CACNG2	NM_006078	na	0.02046	−4.7
Ventricular myocytes
FXYD16,7	NM_021902	H75358	0.00511	2.5
KCNN4	NM_002250	AL552182	0.00551	−1.5
CLCN2	NM_004366	BM789394	0.00391	−1.5
CACNG7	NM_031896	H19702	0.00069	−1.5
CACNG8	NM_031895	CQ718803	0.00092	−1.5
CACNA1A	NM_000068	BF529475	0.01245	−1.5
KCNH6	NM_173092	CQ730511	0.00758	−1.5
CACNG5	NM_145811	AX101266	0.03112	−1.5
GRIN2A	NM_000833	BG718790	0.01562	−1.5
SCNN1D	NM_002978	AK093372	0.00046	−1.6†
GABRA3	NM_000808	DA801686	0.00407	−1.6
CACNA1E19,20	NM_000721	L27745	0.00148	−1.6
KCNH19,21,22	NM_172362	DB021985	0.00092	−1.6
KCNV29,23	NM_133497	CQ724488	0.00935	−1.6
CHRNA6	NM_004198	DA415543	0.00817	−1.6
KCNK69,24	NM_004823	AW883970	0.02392	−1.6
CFTR25	NM_000492	BG386556	0.00212	−1.6
GLRA3	NM_006529	BG186165	0.00657	−1.6
TRPC426,27	NM_016179	AF421361	0.02904	−1.6
FXYD3	NM_021910	DR006067	0.01264	−1.6†
GRIN2D	NM_000836	AB209292	0.00249	−1.6†,‡
CACNA1D9,28,29	NM_000720	CQ731466	0.00347	−1.7
HCN29,30	NM_001194	BX281160	0.00039	−1.7
KCNS19	NM_002251	DA231979	0.02663	−1.7
KCNK1831	NM_181840	AX319992	0.00469	−1.7
VMD232	NM_004183	AA205892	0.03238	−1.7
TRPM133	NM_002420	na	0.02334	−1.7
CHRND34	NM_000751	BF306695	0.01945	−1.7†
CLIC335	NM_004669	BE902424	0.01425	−1.7†
CACNA1H36,37	NM_021098	DB100395	0.00183	−1.7
CACNA1G29	NM_198396	BM451648	0.00045	−1.7
KCND238–40	NM_012281	DA125095	0.01268	−1.7
CNGA3	NM_001298	AK131300	0.02203	−1.7
GABRG2	NM_198904	BI819259	0.02867	−1.8
KCNA49,28,39–41	NM_002233	CQ741592	0.02019	−1.8
ADRA1B42	NM_000679	na	0.02796	−1.8†
CHRNA4	NM_000744	BC096291¶	0.00353	−1.8
CACNA1I	NM_021096	AX068892	0.00270	−1.8
GRIA1	NM_000827	DA749477	0.01665	−1.8
KCNJ19,43	NM_153767	NM_000220	0.00360	−1.8
KCNC39,28	NM_004977	BM474777	0.00913	−1.8
KCNQ49,44	NM_004700	AK074957	0.02336	−1.9
KCNMB245	NM_181361	BG185231	0.01402	−1.9
GABRG1	NM_173536	CQ714573	0.02843	−1.9
KCNG146	NM_172318	DA497732	0.02389	−1.9
KCNE114,47,48	NM_000219	AY789480	0.01744	−1.9
GLRA1	NM_000171	BP208426	0.01999	−2.0
CHRNA1	NM_000079	CD013888	0.02807	−2.0†
NOX149	NM_013954	NM_013955	0.00356	−2.0
GRID2	NM_001510	DB052812	0.00299	−2.0
CHRNA9	NM_017581	BF513332¶	0.00625	−2.0
ADRA2C50–53	NM_000683	T39448	0.00030	−2.1†
GJB1	NM_000166	BF571436	0.01233	−2.1
GABRR1	NM_002042	CB959800	0.01415	−2.1
SCNN1G9	NM_001039	CQ721445	0.00501	−2.2
CNGB3	NM_019098	BX104558	0.00254	−2.5
CHRNB3	NM_000749	DA127065	0.00064	−2.5
GJC154	NM_152219	na	0.00582	−2.5
ADRB152,55,56	NM_000684	na	0.00674	−2.5
KCNG4	NM_172347	CQ728641	0.01073	−2.8
KCTD11	NM_00100291	na	0.00300	−3.1†
KCNA29,16,28,57	NM_004974	BI907383	0.00795	−3.1
GJB6	NM_006783	AY789474	0.00040	−3.5

^*A two-way ANOVA model was used to compare ICM vs. healthy (H) cardiac samples as described in splice microarray data analysis. p-Values, geometric mean (G_mean), and the respective G_fold Change values were calculated.

^†Partial (tiling) human cardiac cDNA clones: AI082799 (KCNJ14); DA560890 (SCNN1D); AI138642, AI144215 and AI183491 (FXYD3); AA455065 (GRIN2D); AA716738 and AI367583 (CHRND); W69541, AI146716 and W69457 (CLIC3); AA010313 (ADRA1B); W81677 (CHRNA1); AAB31164 (ADRA2C); AJ709249 and AJ711264 (KCTD11).

^‡CK845061.1 cDNA from rat ventricle (GRIN2D)

^¶This sequence may represent a bonafide polyA tail.