Table 4.
CE&P genes altered by ICM in atrial and ventricular myocytes
| CE&P class protein | Atrial myocytes | Ventricular myocytes |
|---|---|---|
| Cl− channel | CLIC18, CLIC48 | CLIC335, CLCN2*, CFTR25,58,59, VMD232 |
| Transient outward (Ito) K+ channel, A-type | Kv4.3 (KCND3)*14 | Kv1.4 (KCNA4)*9,28,39–41, Kv3.3 (KCNC3)9,28, Kv4.2 (KCND2)*38–40 |
| Delayed rectifier K+ channel | Kv1.2 (KCNA2)*9,16,28,57, Kv7.4 (KCNQ4)*9,44, Kv10.1 (KCNH1)*9,21,22 | |
| K+ channel modifiers and β subunits | Kv6.1 (KCNG1)46, Kv6.3 (KCNG4), Kv8.2 (KCNV2)*9,23, Kv9.1 (KCNS1)9, minK (KCNE1)*14,47,48,60–62, tetramerization domain containing 11 (KCTD11) | |
| Inward rectifier K+ channel | Kir2.4 (KCNJ14)*9,10 | Kir1.1 (KCNJ1)*9,43, Kv11.2 or HERG2 (KCNH6) |
| Tandem pore domain K+ channel | K2P4.1 (KCNK4)9,15 | K2P6.1 (KCNK6)*9,24, K2P18.1 (KCNK18)31 |
| Ca2+-activated K+ channel | KCa3.1 (KCNN4)*, β2 subunit of maxiK (KCNMB2)45 | |
| Voltage-gated Ca2+ channel α1 subunit63,64 | Cav1.3α1D (CACNA1D)*9,28,29, Cav2.1α1A (CACNA1A)*, Cav2.3α1E (CACNA1E)*19,20, Cav3.1α1G (CACNA1G)*65,66, Cav3.1α1H (CACNA1H)*36,37,67, Cav3.1α1I (CACNA1I), | |
| Ca2+ channel γ subunit | Cavγ2 (CACNG2), Cavγ7 (CACNG7)12 | Cavγ5 (CACNG5), Cavγ7 (CACNG7)12, Cavγ8 (CACNG8) |
| Na+ channel subunits | Navβ1 (SCN1B)*17,18 | ENaC-γ (SCNN1G)*9, ENaC-δ (SCNN1D) |
| TRP channel | TRPC426,27,68, melastatin-1 (TRPM1)33 | |
| Cyclic nucleotide-gated channel69 | HCN2*9,30, CNGA3 | |
| Connexin | Cx32 (GJB1), Cx30 (GJB6), Cx31.9 (GJC1)54,70,71 | |
| Acetylcholine receptor72 | α10 (CHRNA10)11 | α1 (CHRNA1), α4 (CHRNA4), α6 (CHRNA6), α9 (CHRNA9), β3 (CHRNB3), δ(CHRND)34 |
| Glycine receptor | α1 (GLRA1), α3 (GLRA3) | |
| GABA receptor | α3 (GABRA3)*, γ1 (GABRG1), γ2 (GABRG2), rho (GABRR1) | |
| NMDA receptor receptor73,74 | 2A (GRIN2A), 2D (GRIN2D) | |
| Glutamate receptor receptor73,74 | AMPA3 (GRIA3)*13 | AMPA1 (GRIA1), d2 (GRID2) |
| Adrenergic receptor75 | α1B (ADRA1B)42,76–78, α2C (ADRA2C)50,52,53, β1 (ADRB1)*52,56 | |
| H+ channel | NADPH oxidase (NOX1)49 | |
| Na+,K+-ATPase regulator | FXYD1*7, FXYD7 | FXYD1*7, FXYD3 |
*
Mouse Genome Database gene expression data (www.informatics.jax.org) confirming expression of the marked genes in mouse heart.