Table 3.

Multivariate Analysis: Risk Factors Associated with Increased Mortality beyond 1 Year Post Liver Transplant (LT).

Overall Death
Risk Factor	HR	CI	Pvalue
Overall Death ^
Age in decades	1.24	1.09–1.41	<0.001
Diabetes pre-LT	1.48	1.06–2.08	0.023
Renal insufficiency pre or post-LT*	3.59	2.50–5.16	<0.001
Cholestatic Disease pre-LT	0.45	0.32–0.65	<0.001
HCC	1.76	1.13–2.72	0.011
CCA	3.22	1.17–8.81	0.023
Retransplant > 1year ^^	5.04	2.83–8.96	<0.001
Liver-related Death
HCV diagnosis	2.61	1.57–4.35	<0.001
Renal insufficiency pre or post-LT*	5.10	2.41–10.77	<0.001
Diabetes pre or post LT*	1.85	1.21–3.05	0.016
Retransplant > 1year ^^	8.50	3.77–19.16	<0.001
Cardiovascular Death
Age in decades	2.12	1.34–3.36	0.001
Cryptogenic cirrhosis pre-LT	5.59	2.04–15.29	<0.001
Alcoholic liver disease pre-LT	4.79	1.73–13.27	0.003
Malignancy Death
Age in decades	1.46	1.11–1.93	0.007
Cholestatic disease pre-LT	0.47	0.23–0.98	0.043
Renal insufficiency pre or post-LT*	2.66	1.35–5.25	0.005
HCC	2.80	1.30–6.01	0.008
CCA	12.48	3.65–42.69	<0.001

^{^}Multivariate analysis for Overall death after 5years showed similar HR, see text.

^*Time dependent factor analysis

ALD = alcohol related disease, HCC = hepatocellular carcinoma, CCA = cholangiocarcinoma

^{^^}Retransplant >1 year after primary transplant.

Note: Renal related deaths were too few to perform multivariate analysis