Table 1.

The main effect of drug group [F(1, 8)=8.7, p< 0.05] was evident with ketamine administration compared to placebo

A main effect of time [F(4, 32)= 6.8, p<0.05] was also evident. BPRS scores increased during ketamine loading dose and steady-state time points and decreased following nicotine administration

Group/rating	Baseline	Post-loading	Steady state	Post-nicotine	Recovery
Placebo/nicotine
BPRS positive	5 (0)	5 (0)	5 (0)	5 (0)	5 (0)
BPRS negative	4 (0)	4 (0)	4 (0)	4 (0)	4 (0)
BPRS total	20.1(0.4)	20.1 (0.4)	20.1(0.4)	20 (0)	20 (0)
Ketamine/nicotine
BPRS positive	5.1 (0.3)	5.7 (1.1)	5.1 (0.3)	5 (0)	5 (0)
BPRS negative	4 (0)	6.1 (1.8)	4.6 (0.7)	4.2 (0.67)	4 (0)
BPRS total	20.2(0.45)	23.8 (3.7)	21.3 (2.4)	20.2 (0.67)	20 (0)