Table 2.
Image contrast statistics are based on a minimum cluster size of 100 voxels, above a threshold of T=2.36, p=0.01 (voxel size=2×2× 2 mm, one resel=164 voxels)
| Region Name | BA | Cluster Size (Voxel Number) |
P_corrected | P_uncorrected | Voxel Z max | x | y | z |
|---|---|---|---|---|---|---|---|---|
| Nicotine−placebo | ||||||||
| Increase | ||||||||
| Lateral occipital gyrus (L) | 18 | 284 | 0.283 | 0.005 | 3.9 | −26 | −76 | −8 |
| Lateral occipital gyrus (R) | 18 | 220 | 0.53 | 0.012 | 4 | 36 | −78 | −6 |
| Decrease | ||||||||
| Dentate nucleus (cerebellum) (R) | * | 413 | 0.073 | 0.001 | 5 | 20 | −42 | −26 |
| Ventral striatum and putamen (L) | * | 2,269 | 0.0001 | 0.0001 | 4.8 | −16 | 6 | −8 |
| Globus pallidus and putamen | * | 747 | 0.003 | 0.0001 | 4.6 | 26 | −2 | −4 |
| Anterior cingulate (midline) | 32 & 8 | 341 | 0.155 | 0.003 | 3.6 | −2 | 32 | 36 |
| Posterior cingulate and precuneus | 31 & 7 | 708 | 0.004 | 0.0001 | 3.5 | 0 | −26 | 46 |
| Superior frontal cortex (R) | 9 | 437 | 0.057 | 0.001 | 3.4 | 20 | 54 | 30 |
| Ketamine−placebo | ||||||||
| Increase | ||||||||
| Orbital frontal cortex (R) | 11 and 25 | 521 | 0.024 | 0.0001 | 5.2 | 20 | 14 | −22 |
| Insula (L) | * | 1,282 | 0.0001 | 0.0001 | 4.4 | −38 | 16 | 10 |
| Gyrus rectus (R) | 11 | 1,685 | 0.0001 | 0.0001 | 4 | 8 | 48 | −24 |
| Orbital frontal cortex (R) | 11 | 984 | 0.0001 | 0.0001 | 3.9 | 44 | 40 | −18 |
| Middle frontal cortex (L) | 9 | 544 | 0.019 | 0.0001 | 3.7 | −30 | 48 | 36 |
| Decrease | ||||||||
| Hippocampus/parahippocampus (L) | 36 | 1,228 | 0.0001 | 0.0001 | 5.1 | −34 | −38 | −10 |
| Dentate nucleus (cerebellum) (R) | * | 5,583 | 0.0001 | 0.0001 | 5 | 24 | −50 | −24 |
| (Ketamine+nicotine)−placebo | ||||||||
| Increase | ||||||||
| Orbital frontal cortex (midline) | 11 and 25 | 7,195 | 0.0001 | 0.0001 | 6.8 | −4 | 30 | −24 |
| Precuneus (L) | 7 and 19 | 327 | 0.18 | 0.003 | 3.9 | −14 | −56 | 34 |
| Decrease | ||||||||
| Dentate nucleus (cerebellum) (R) | * | 12,427 | 0.0001 | 0.0001 | 5 | 22 | −48 | −26 |
| Anterior cingulate cortex (midline) | 32 and 6 | 1,309 | 0.0001 | 0.0001 | 5 | 6 | 6 | 46 |
| Precentral gyrus | 4 | 636 | 0.008 | 0.0001 | 4.5 | −40 | −16 | 40 |
| Amygdala (R) | * | 437 | 0.057 | 0.001 | 4.3 | 12 | −10 | −24 |
| (Ketamine+nicotine)−nicotine | ||||||||
| Increase | ||||||||
| Orbital frontal cortex (midline) | 11 and 25 | 11,103 | 0.0001 | 0.0001 | 5.5 | −4 | 32 | −22 |
| Superior Frontal Cortex (R) | 9 | 413 | 0.073 | 0.001 | 4.3 | 18 | 52 | 28 |
| Decrease | ||||||||
| Dentate nucleus (cerebellum) (L) | * | 10,596 | 0.0001 | 0.0001 | 5.3 | −24 | −70 | −20 |
| Superior temporal gyrus (R) | 22 | 298 | 0.245 | 0.004 | 5.1 | 46 | −24 | 14 |
| Superior temporal gyrus (L) | 22 | 631 | 0.008 | 0.0001 | 3.9 | −50 | −26 | 0 |
| Lateral occipital gyrus (L) | 18 | 398 | 0.085 | 0.001 | 4.7 | −32 | −92 | 22 |
| (Ketamine+nicotine)−ketamine | ||||||||
| Increase | ||||||||
| Orbital frontal cortex (midline) | 11 and 25 | 1,469 | 0.0001 | 0.0001 | 6.3 | 4 | 30 | −30 |
| Precuneus (L) | 7 and 19 | 509 | 0.027 | 0.0001 | 4.1 | −18 | −62 | 42 |
| Decrease | ||||||||
| Dentate Nucleus (Cerebellum) (L) | * | 1,646 | 0.0001 | 0.0001 | 5.1 | −22 | −56 | −32 |
| Dentate Nucleus (Cerebellum) (R) | * | 505 | 0.028 | 0.0001 | 4.2 | 18 | −46 | −26 |
| Superior Temporal Gyrus (L) | 38 | 1,932 | 0.0001 | 0.0001 | 4.8 | −42 | 8 | −16 |