. Author manuscript; available in PMC: 2011 Jun 1.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2010 Apr 17;3(3):222–229. doi: 10.1161/CIRCEP.110.944934

Table 2. Cohort Specific Associations between rs2283222 in KCNQ1 and rs11720524 in SCN5A and Sudden Cardiac Death.

Shown are the individual cohort specific and combined meta-analysis odds ratios (95% CI) for increasing copy of the “at risk” T allele of rs2283222 in KCNQ1 and C allele of rs11720524 in SCN5A from the conditional logistic regression models under an additive model of inheritance.

Cohort	Case/ control	rs2283222 (KCNQ1)				rs11720524 (SCN5A)

		n	Frequency of T- Allele	OR per T-Allele (95% CI)	P-value	n	Frequency of C- Allele	OR per C-Allele (95% CI)	P-value

HPFS	case	116	0.720	1.24 (0.90-1.72)	0.18	116	0.599	1.08 (0.80-1.46)	0.62
HPFS	control	340	0.671	1.24 (0.90-1.72)	0.18	339	0.586	1.08 (0.80-1.46)	0.62

PHS I	case	130	0.735	1.27 (0.92-1.75)	0.15	132	0.686	1.40 (1.04-1.87)	0.03
PHS I	control	378	0.689	1.27 (0.92-1.75)	0.15	385	0.608	1.40 (1.04-1.87)	0.03

PHS II	case	72	0.771	1.58 (1.02–2.44)	0.04	73	0.623	1.12 (0.76-1.64)	0.56
PHS II	control	208	0.676	1.58 (1.02–2.44)	0.04	212	0.594	1.12 (0.76-1.64)	0.56

NHS	case	109	0.734	1.57 (1.12-2.21)	0.01	108	0.690	1.56 (1.12-2.17)	0.008
NHS	control	320	0.636	1.57 (1.12-2.21)	0.01	317	0.585	1.56 (1.12-2.17)	0.008

WACS	case	37	0.770	1.69 (0.92-3.11)	0.09	36	0.653	1.34 (0.77-2.35)	0.30
WACS	control	109	0.665	1.69 (0.92-3.11)	0.09	106	0.590	1.34 (0.77-2.35)	0.30

WHS	case	38	0.697	0.99 (0.56 -1.73)	0.96	38	0.724	1.53 (0.86-2.75)	0.15
WHS	control	103	0.704	0.99 (0.56 -1.73)	0.96	106	0.632	1.53 (0.86-2.75)	0.15

Meta- analysis	case	502	0.736	1.36 (1.16-1.60)	0.0002	503	0.658	1.30 (1.12-1.51)	0.0005
Meta- analysis	control	1458	0.670	1.36 (1.16-1.60)	0.0002	1465	0.596	1.30 (1.12-1.51)	0.0005