Table 3. Multivariable and Sensitivity Analyses.

Association of sudden cardiac death with two ion channel variants. Shown are the meta-analysis odds ratios (95% CI) with increasing levels of risk factor adjustment for increasing copy of the T-allele of rs2283222 in KCNQ1 and the C-allele of rs11720524 in SCN5A.

Genetic Variant	OR(95% CI) for All SCD (Primary Analysis)	P-value	OR(95% CI) for Definite SCD* (N= 425)	P-value
rs2283222
Age-adjusted	1.36 (1.15-1.59)	0.0002	1.33 (1.11-1.59)	0.002
Multivariate Model 1†	1.37 (1.16-1.63)	0.0003	1.34 (1.11-1.63)	0.003
Multivariate Model 2‡	1.39 (1.16-1.66)	0.0003	1.36 (1.11-1.67)	0.003
rs11720524
Age-adjusted	1.31 (1.12-1.52)	0.0005	1.32 (1.12-1.56)	0.001
Multivariable Model 1†	1.33 (1.13-1.55)	0.0004	1.35 (1.13-1.62)	0.0009
Multivariate Model 2‡	1.34 (1.13-1.58)	0.0007	1.35 (1.12-1.64)	0.002

^*Sensitivity Analysis: Excluding probable sudden cardiac death cases (i.e. Unwitnessed deaths or deaths that occurred during sleep where the participant was documented to be symptom free when last observed within the preceding 24 hours)

^†Multivariable Model 1: Controlled simultaneously for age, smoking status (current, past, never), BMI (continuous), history of diabetes, hypertension, and high Cholesterol.

^‡Multivariable Model 2: Controlled for variables listed above in multivariable Model 2 and family history of myocardial infarction, alcohol intake (<weekly, weekly, daily, 2 or more per day); physical activity (at least once per week) and aspirin (> or = 11 days/month