Table 4. Association between Ion Channel Amino Acid Polymorphisms and Sudden Cardiac Death.
Primary fixed-effects meta-analysis odds ratios and 95 percent confidence intervals for the minor allele according to additive, dominant and recessive modes of inheritance
| Gene | Amino Acid Change |
SNP ID | Genomic Context |
Allele (A/a) |
MAF | Additive | Dominant | Recessive | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P | ||||||
| KCNE1 | D85N | rs1805128 | 34743550 | G/a | 0.02 | 1.18 | (0.60-2.31) | 0.63 | 1.18 | (0.60-2.31) | 0.63 | - | - | - |
| KCNE1 | S38G | rs1805127 | 34743691 | C/t | 0.35 | 1.02 | (0.88-1.19) | 0.77 | 1.14 | (0.93-1.41) | 0.20 | 0.82 | (0.59-1.12) | 0.21 |
| KCNE2 | T8A | rs2234916 | 34664669 | A/g | 0.01 | 1.12 | (0.31-4.03) | 0.87 | 1.12 | (0.31-4.03) | 0.87 | - | - | - |
| KCNH2 | K897T | rs1805123 | 150083182 | A/c | 0.23 | 0.91 | (0.76-1.10) | 0.32 | 0.89 | (0.72-1.10) | 0.28 | 1.02 | (0.59-1.77) | 0.93 |
| SCN5A | H558R | rs1805124 | 38620424 | A/g | 0.23 | 1.08 | (0.91-1.27) | 0.39 | 1.14 | (0.92-1.40) | 0.23 | 0.94 | (0.61-1.46) | 0.79 |