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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Neurobiol Dis. 2010 Mar 27;39(2):127–137. doi: 10.1016/j.nbd.2010.03.016

Figure 3. Cuprizone-induced loss of oligodendrocytes and subsequent repopulation during recovery in placebo and E2-treated mice.

Figure 3

A. Representative images of GSTpi+ mature oligodendrocytes in the corpus callosum of placebo and E2-treated mice during cuprizone administration and recovery. The inset in the no cuprizone, placebo image shows an example of a GSTpi-positive cell (red, filled arrowhead) overlayed with DAPI nuclei counterstain (blue, open arrowhead). DAPI overlayed images were used for quantification. Scale bar represents 50 micrometers.

B. Quantification of GSTpi+ mature oligodendrocytes. Individual data points and mean bars are plotted for 10–15 animals per group at each time point. * p < 0.05. At the 3 and 5 week time points, E2-treated mice that exhibited the greatest protection from demyelination (Figure 2B) are indicated with filled circles.