Figure 1.
AA modulates MMP-2 and MMP-9 activity in LHBETATAG transgenic RB. A single subconjunctival injection of 300 mg AA was administered in the right eye (T) of the LHBETATAG transgenic RB mice, while the right fellow eye (F) remained untreated. Whole eye extracts were analyzed by gel zymography to measure MMP-2 () and MMP-9 (■) activities at 24 hours, 48 hours, and 1 week after injection. Top: gelatin zymogram from a representative experiment. Mouse recombinant MMP-9 and MMP-2 were used as positive controls (M). Bottom: average results of three independent gel zymograms. Error bars represent standard deviations from the mean. WT, wild-type; RB, LHBETATAG.