Table 3.
EP Modulation of Cell-Cycle Control Signaling
| Panel | Gene Title | Gene Symbol | EP Effect | K, M |
|---|---|---|---|---|
| 204859_s_at | Apoptotic peptidase activating factor 1 | APAF1 | −2.51 | 1, 2 |
| 212672_at | Ataxia telangiectasia mutated (includes complementation groups A, C and D) | ATM | −2.39 | 1, 2 |
| 202095_s_at | Baculoviral IAP repeat-containing 5 (survivin) (also 202094_at, 210334_x_at) | BIRC5 | −6.38 | 2, 2 |
| 204531_s_at | Breast cancer 1, early onset | BRCA1 | −3.13 | 2, 3 |
| 219099_at | Chromosome 12 open reading frame 5 | C12orf5 | 3.24 | 2, 3 |
| 214710_s_at | Cyclin B1 (also 228729_at) | CCNB1 | −5.43 | 2, 3 |
| 202705_at | Cyclin B2 | CCNB2 | −5.17 | 0, 2 |
| 203213_at | Cell division cycle 2, G1 to S and G2 to M (also 203214_x_at, 210559_s_at) | CDC2 | −10.45 | 1, 2 |
| 205167_s_at | Cell division cycle 25 homolog C (S. pombe) | CDC25C | −3.97 | 2, 2 |
| 204252_at | Cyclin-dependent kinase 2 | CDK2 | −2.40 | 2, 2 |
| 202284_s_at | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | CDKN1A | 3.96 | 2, 1 |
| 205394_at | CHK1 checkpoint homolog (S. pombe) also 205393_s_at | CHEK1 | −3.12 | 0, 2 |
| 242560_at | Fanconi anemia, complementation group D2 | FANCD2 | −6.66 | 0, 2 |
| 203725_at | Growth arrest and DNA-damage-inducible, alpha | GADD45A | 4.87 | 0, 2 |
| 217373_x_at | Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) (also 205386_s_at) | MDM2 | 3.50 | 1, 2 |
| 205024_s_at | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | RAD51 | −4.61 | 1, 2 |
| 223342_at | Ribonucleotide reductase M2 B (TP53 inducible) | RRM2B | 3.07 | 1, 2 |
| 213253_at | Structural maintenance of chromosome 2 | SMC2 | −3.01 | 2, 3 |
| 235086_at | Thrombospondin 1 (also 201107_s_at) | THBS1 | −4.33 | 1, 3 |
| 209294_x_at | Tumor necrosis factor receptor superfamily, member 10b (also 209295_at, 210405_x_at) | TNFRSF10B | 2.33 | 2, 3 |
| 201291_s_at | Topoisomerase (DNA) II alpha 170kDa (also 201292_at) | TOP2A | −10.46 | 0, 2 |
| 225912_at | Tumor protein p53 inducible nuclear protein 1 | TP53INP1 | 3.34 | 1, 2 |
The “EP effect” is the mean of the valid expression changes only. The number of valid expression changes in keratocytes (K) and myofibroblasts (M) are given in the column headed K, M (e.g., 1,2 denotes one valid keratocyte change and two valid myofibroblast changes).