Table 2.
Effect of Oral Tadalafil on IOP of Normal Sheep Measured with Applanation Tonometry
| Sheep No. |
Mean IOP | n | SEM | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 033 |
034 |
035 |
036 |
||||||||
| OD | OS | OD | OS | OD | OS | OD | OS | ||||
| Sex | F | F | F | F | |||||||
| Baseline IOP (0 h) | 9.4 | 9.4 | 9.4 | 9.4 | 10.5 | 9.4 | 9.4 | 9.4 | 9.6 | 8 | 0.1 |
| IOP at 1 h | 13.7 | 13.7 | 14.8 | 17.0 | 15.9 | 13.7 | 15.9 | 15.9 | 15.1* | 8 | 0.4 |
| IOP at 2 h | 18.1 | 19.1 | 17.0 | 18.1 | 19.1 | 18.1 | 18.1 | 18.1 | 18.2* | 8 | 0.2 |
| IOP at 48 h | 17.0 | 15.9 | 12.7 | 14.8 | 17.0 | 13.7 | 13.7 | 15.9 | 15.1* | 8 | 0.6 |
Tadalafil (20 mg) was administered orally within 1 minute of the recording of baseline IOP, IOP was remeasured 1, 2, and 48 hours after drug ingestion. Recorded values with Perkins tonometer were converted to mm Hg according to a calibration curve for sheep eyes (Gerometta et al.12). IOP returned to baseline within 4 days of tadalafil ingestion.
*
Significantly higher than baseline IOP as paired data, P < 2 × 10−5.