Table 3.

Effects of Oral Sildenafil on IOP and AH Protein Levels of Normal Sheep

	Sheep No.												Mean	n	SEM
	392		393		040		041		045		034
	OD	OS	OD	OS	OD	OS	OD	OS	OD	OS	OD	OS
Baseline IOP	9.4	9.4	9.4	9.4	9.4	9.4	9.4	10.5	9.4	9.4	9.4	9.4	9.5	12	0.1
Baseline protein content (μg/μL)		0.057		0.075	0.056			0.127	0.042		0.096		0.076	6	0.013
IOP (at 80 min)	19.1	15.9	21.3	18.1	20.2	22.4	22.4	20.2	22.4	22.4	22.4	23.4	20.8*	12	0.6
Protein content (μg/μL)	0.171		0.086			0.094	0.198			0.048		0.132	0.122†	6	0.023

Paracentesis of the anterior chamber for the protein assay was performed on one eye of six female sheep, followed by oral administration of sildenafil (100 mg) within 3 minutes of the recording of baseline IOP. IOP was remeasured 80 minutes after drug ingestion. IOP values in bold indicate the eye from which AH was removed. Paracentesis was performed on the fellow eye immediately after the second IOP measurement. The IOP of the sampled fellow eye is shown in bold. In this manner, AH was sampled from each eye only once, and the effects of sildenafil on AH protein levels were determined by comparing the protein contents of the anterior chambers from the contralateral eyes.

^*IOP significantly higher as paired data, P < 3 × 10⁻⁹.

^†Protein content significantly higher as paired data, P < 0.04.