Figure 7.

The LP was reduced in the heterozygous Clcn2^nmf240 mice. (A) Average dc-ERGs recorded from WT (n = 11) and Clcn2^nmf240 heterozygotes (n = 9) in response to a 7-minute, 2.4-log cd/m² stimulus. (B) Average ± SEM measures for the major components of the dc-ERG from the WT (n = 11) and Clcn2^nmf240 heterozygous (n = 9) mice. There was no difference between the WT and Clcn2^nmf240 heterozygous mice in the amplitude of the c-wave, FO, or off-response. The LP component was significantly reduced in the heterozygous mutants.