Table 3.

Statistical Analyses of Regions of Interest (Omnibus Repeated-Measures ANOVA)

Effect^a	Patients With Comorbid MDD/Anxiety Included^b						Patients With Comorbid MDD/Anxiety Excluded^c
	Left Amygdala			Right Amygdala			Left Amygdala			Right Amygdala
	F Value	df	P Value	F Value	df	P Value	F Value	df	P Value	F Value	df	P Value
Main effect
Group (between-subject effect)	0.98	2, 84	.38	1.25	2, 84	.29	0.52	2, 70	.60	1.40	2, 70	.25
Emotion (within-subject effect)	6.49	2.9, 240.1	<.001^d	3.34	2.6, 219.2	.03^d	4.45	2.8, 194.2	.006^d	1.70	2.5, 177.4	.18
Attention (within-subject effect)	7.53	2.8, 238.5	<.001^d	0.16	2.8, 236.2	.91	5.66	2.8, 196.1	.001^d	0.15	2.6, 185.1	.91
2-Way interaction
Group × emotion	2.16	5.7, 240.1	.05	1.80	5.2, 219.2	.11	2.02	5.6, 194.2	.07	1.94	5.1, 177.4	.09
Group × attention	3.00	5.7, 238.5	.009^d	0.88	5.6, 236.2	.50	2.74	5.6, 196.1	.02^d	0.63	5.3, 185.1	.69
Emotion × attention	1.21	7.4, 621.1	.30	1.69	6.6, 553.6	.12	1.45	7.2, 505.0	.18	1.31	6.0, 416.6	.25
3-Way interaction
Group × emotion × attention	2.68	14.8, 621.1	.001^d	2.01	13.2, 553.6	.02^d	2.71	14.4, 505.0	.001^d	1.90	11.9, 416.6	.03^d

Abbreviations: ANOVA, analysis of variance; MDD, major depressive disorder.

Results of omnibus repeated-measures analyses of variance (Greenhouse-Geisser corrected). “Group” includes MDD, anxiety, and control; “emotion,” neutral, fearful, angry, and happy; “attention,” hostile, afraid, nose, and passive.

Patients with MDD with and without comorbid anxiety disorder (n=26), patients with anxiety (n=16), and healthy controls (n=45).

Patients with MDD without comorbid anxiety disorder (n=12), patients with anxiety (n=16), and healthy controls (n=45).

Significant at P < .05.