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. 2003 Dec 1;17(23):2966–2978. doi: 10.1101/gad.1122403

Figure 1.

Figure 1.

Proneural proteins directly regulate sens transcription. (A) Schematic of genomic fragments used to identify sens enhancers. (B-F) Patterns generated by various fragments identified in A in stage 14 or 15 embryos. Anterior is to the left, dorsal to the top. (G) Sequence of the 9-1 fragment showing a single E box (highlighted in yellow). Blue residues are identical to a similar fragment in the 5′-UTR of the sens homolog in D. pseudoobscura. (H) Expression of lacZ conferred by the E box-mutated 9-1 fragment in a stage 15 embryo. (I) EMSA using wild-type (wt) and mutant (m) probes that correspond to the sequence underlined in G. Note that Da, Da/Ato, and Da/Ac are all able to bind this site.