Figure 5.
Spontaneous diabetes in oligoclonal and monoclonal 4.1-NOD, 4.1-NOD.PO+/–, and 4.1-NOD.PO–/– mice. (a) Oligoclonal mice. Data correspond to 57 female and 49 male 4.1-NOD mice, 21 female and 20 male 4.1-NOD.PO+/– mice, and 63 female and 42 male 4.1-NOD.PO–/– mice. The incidence of diabetes in 4.1-NOD.PO–/– mice was significantly lower than in 4.1-NOD mice (P < 0.02). (b) Monoclonal mice. Data correspond to 74 female and 70 male RAG-2–/– 4.1-NOD mice, and 31 female and 18 male RAG-2–/– 4.1-NOD.PO–/– mice.