Table 1.
The distribution of the GST genotypes in Black and Mixed Ancestry in South Africans
| Genotypes | Black African subjects | Mixed Ancestry subjects | Analysis of subjects combined | |||
|---|---|---|---|---|---|---|
| Patients N (%) |
Controls N (%) |
Patients N (%) |
Controls N (%) |
OR 1 (95%CI) p-value | OR2 (95%CI) p-value | |
| GSTT1a | ||||||
| *1 | 57 (40) | 109 (59) | 68 (68) | 69 (73) | 1.00 | 1.00 |
| *0 (rs71748309) | 84 (60) | 77 (41) | 29 (29) | 25 (27) | 1.55 (1.09-2.21) 0.014 | 1.71 (1.18-2.46) 0.004 |
| GSTP1 313 A/G (Ile105Val) (rs1695) | ||||||
| 313A/A | 56 (40) | 76 (41) | 34 (34) | 30 (32) | 1.00 | |
| 313A/G | 59 (42) | 83 (45) | 52 (52) | 51 (54) | 0.96 (0.66-1.40) 0.846 | 1.01 (0.68-1.48) 0.973 |
| 313G/G | 26 (18) | 27 (14) | 11 (11) | 13 (14) | 1.08 (0.64-1.82) 0.786 | 1.21 (0.71-2.07) 0.490 |
| Test for deviation from Hardy-Weinberg Equilibrium | ||||||
| χ2 | 2.139 | 0.360 | 1.874 | 1.407 | ||
| p | 0.144 | 0.549 | 0.177 | 0.236 | ||
| 313A freq | 0.61+0.03 | 0.63+0.02 | 0.62+0.03 | 0.59+0.03 | ||
| 313G freq | 0.39+0.03 | 0.37+0.02 | 0.38+0.03 | 0.41+0.03 | ||
| GSTP1 341 C/T (Ala114Val) (rs1138272) | ||||||
| 341C/C | 85 (60) | 163 (88) | 65 (65) | 89 (95) | 1.00 | 1.00 |
| 341C/T | 49 (35) | 21 (11) | 27 (27) | 5 (5) | 4.98 (3.05-8.11) 0.001 | 5.05 (3.06-8.32) 0.001 |
| 341T/T | 7 (5) | 2 (1) | 5 (5) | 0 (0) | 10.9 (2.43-49.1) 0.002 | 9.58 (2.08-44.0) 0.004 |
| Test for deviation from Hardy-Weinberg Equilibrium | ||||||
| χ2 | 0 | 1.397 | 0.876 | 0.137 | ||
| p | 0.986 | 0.237 | 0.349 | 0.712 | ||
| 341C freq | 0.78+0.02 | 0.93+0.01 | 0.81+0.03 | 0.97+0.01 | ||
| 341T freq | 0.22+0.02 | 0.07+0.01 | 0.19+0.03 | 0.03+0.01 | ||
OR1, odds ratio not adjusted for confounders; OR2, odds ratio adjusted for the following confounding variables, age, sex, race, tobacco smoking, alcohol consumption and use of wood or charcoal; . a *1 signifies carrier of gene (either homozygous or heterozygous carrier), *0 signifies homozygous gene deletion