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. 2010 May 26;10:238. doi: 10.1186/1471-2407-10-238

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Copyright ©2010 Vanamala et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of Resveratrol and treatment on apoptosis. A - Resveratrol but not IGF-1R siRNA induces apoptosis in HT-29 cells. Percentage induction of apoptosis was determined by TUNEL assay. The rate of apoptosis was expressed as a percentage of the total cells counted. Results are expressed as mean ± SE for the different treatments in both non specific siRNA and IGF-1R siRNA transfected cells. * indicates significant elevation compared to solvent control (DMSO). ^$indicates elevation (p < 0.05) by treatments compared to non specific siRNA control. B - Resveratrol treatment elevated cleaved PARP, a hallmark of apoptosis. Cells were treated with resveratrol (50, 100 and 150 μM) alone or IGF-1 (10 nM) for 5 minutes followed by resveratrol at different concentrations and analyzed by western blot as described in materials and methods. Similar results were obtained in duplicate experiments.