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Doxorubicin fails to protect p53–/– cells. (a) Effects of doxorubicin on p53 and p21 proteins in HCT116, p21–/–, and p53–/– cells. Cells were incubated with (+) or without (–) 100 ng/mL doxorubicin for 16 hours and then assayed by immunoblot analysis. (b) Cells were pretreated with 100 ng/mL doxorubicin as indicated (DOX) and continued with or without 100 ng/mL paclitaxel (PTX). Cell survival was measured by MTT assay 2 days after PTX addition.
