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. 2010 Jun 24;6(6):e1000826. doi: 10.1371/journal.pcbi.1000826

Figure 1. Schematic of the sleep model.

Figure 1

Bihemispheric model [18] (gray box), and its extension to model unihemispheric sleep, including MA and VLPO populations, and circadian (C), homeostatic (H), and cholinergic/orexinergic (ACh/Orx) drives. Arousal state feeds back to H. Pointed and rounded arrowheads indicate excitatory and inhibitory connections, respectively. To model unihemispheric sleep we add an inhibitory VLPO-VLPO connection (dotted arrows). Time series are shown alongside MA and H, showing simulated human bihemispheric (top) and dolphin unihemispheric sleep (bottom), with solid and dashed lines distinguishing the hemispheres.