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Effect of exogenous recombinant HDGF on SMC proliferation. SMCs in SFM with (a) or without (b) heparin were cultured for 72 hours with vehicle (control) or HDGF (10 ng–2 μg/mL) and assayed for cell number. Cell numbers per condition were expressed as percent increase over controls. For controls, n = 8; for HDGF, n = 4 per concentration. The entire experiment was repeated twice in 2 separate experiments. *P < 0.05 by one-way ANOVA control versus HDGF.
