Table 3.
Genotypes in Danish patients with ulcerative colitis1.
| Ncase | Ncontrol | OR (95%CI)2 | OR (95%CI)3 | OR (95%CI)4 | P-value5 | ||||
|---|---|---|---|---|---|---|---|---|---|
| IL1 β C-31T (rs1143627) | |||||||||
| TT | 204 | 342 | 1.00 | - | 1.00 | - | 1.00 | - | |
| CT | 238 | 342 | 1.17 | (0.92-1.48) | 1.15 | (0.90-1.47) | 1.15 | (0.89-1.47) | 0.28 |
| CC | 56 | 95 | 0.99 | (0.68-1.43) | 0.99 | (0.68-1.46) | 1.02 | (0.69-1.49) | 0.94 |
| CT and CC | 294 | 437 | 1.13 | (0.90-1.42) | 1.11 | (0.88-1.41) | 1.12 | (0.88-1.42) | 0.35 |
| IL-10 C-592A (rs1800872) | |||||||||
| CC | 328 | 483 | 1.00 | - | 1.00 | - | 1.00 | - | |
| AC | 149 | 261 | 0.84 | (0.66-1.07) | 0.83 | (0.65-1.07) | 0.83 | (0.64-1.07) | 0.14 |
| AA | 21 | 35 | 0.88 | (0.51-1.55) | 0.99 | (0.56-1.76) | 1.00 | (0.56-1.77) | 0.99 |
| AC and AA | 170 | 296 | 0.85 | (0.67-1.07) | 0.85 | (0.67-1.08) | 0.85 | (0.66-1.08) | 0.18 |
| IL-10 C-819T (rs1800871) | |||||||||
| CC | 325 | 483 | 1.00 | - | 1.00 | - | 1.00 | - | |
| CT | 151 | 259 | 0.87 | (0.68-1.11) | 0.86 | (0.67-1.11) | 0.85 | (0.66-1.10) | 0.22 |
| TT | 22 | 37 | 0.88 | (0.51-1.53) | 1.00 | (0.57-1.74) | 1.00 | (0.57-1.75) | 0.99 |
| CT and TT | 173 | 296 | 0.87 | (0.69-1.10) | 0.88 | (0.69-1.12) | 0.87 | (0.68-1.11) | 0.27 |
| IL-10 G-1082A (rs1800896) | |||||||||
| GG | 169 | 238 | 1.00 | - | 1.00 | - | 1.00 | - | |
| AG | 239 | 374 | 0.90 | (0.70-1.16) | 0.91 | (0.70-1.19) | 0.93 | (0.72-1.22) | 0.61 |
| AA | 90 | 167 | 0.76 | (0.55-1.05) | 0.78 | (0.56-1.08) | 0.76 | (0.54-1.06) | 0.10 |
| AG and AA | 329 | 541 | 0.86 | (0.67-1.09) | 0.87 | (0.68-1.12) | 0.88 | (0.68-1.13) | 0.31 |
| (rs3024505) | |||||||||
| CC | 297 | 522 | 1.00 | - | 1.00 | - | 1.00 | - | |
| CT | 172 | 235 | 1.29 | (1.01-1.64) | 1.35 | (1.05-1.73) | 1.34 | (1.04-1.73) | 0.02 |
| TT | 29 | 22 | 2.32 | (1.31-4.11) | 2.37 | (1.31-4.29) | 2.31 | (1.27-4.20) | 0.01 |
| CT and TT | 201 | 779 | 1.37 | (1.09-1.74) | 1.43 | (1.13-1.83) | 1.43 | (1.12-1.82) | 0.004 |
| HO-1 A-413T (rs2071746) | |||||||||
| AA | 162 | 267 | 1.00 | - | 1.00 | - | 1.00 | - | |
| AT | 251 | 373 | 1.11 | (0.86-1.43) | 1.10 | (0.85-1.42) | 1.11 | (0.85-1.44) | 0.45 |
| TT | 85 | 139 | 1.01 | (0.72-1.41) | 1.00 | (0.71-1.41) | 1.01 | (0.71-1.42) | 0.98 |
| AT and TT | 336 | 512 | 1.08 | (0.85-1.37) | 1.07 | (0.84-1.37) | 1.08 | (0.84-1.38) | 0.55 |
1OR = Odds Ratio, 95%CI = 95% confidence interval,
2 Crude,
3 Adjusted for age and gender,
4 Adjusted for age, gender and smoking status.
5P for the fully adjusted estimate