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. Author manuscript; available in PMC: 2011 Jun 9.
Published in final edited form as: J Am Chem Soc. 2010 Jun 9;132(22):7617–7625. doi: 10.1021/ja909370k

Figure 4.

Figure 4

Structures of DNA-pol β ternary complexes with monochloro, monobromo and monomethyl β,γ-CXY dGTP analogues. The Fo−Fc simulated annealing electron density omit maps (light blue) contoured at 4σ show electron density for the corresponding β,γ-dGTP analogue. (a) Both stereoisomers of β,γ-CHCl-dGTP (6, 7) are observed in the ternary complex. The chlorine atoms are purple; the carbon atoms of the (R)-isomer (6) are yellow while those of the (S)-isomer (7) are gray. (b) Both stereoisomers of β,γ-CHBr-dGTP (8, 9) are observed in the ternary complex. The bromine atoms are dark red; the carbon atoms of the (R)-isomer (8) are yellow, while those of the (S)-isomer (9) are gray. (c) Both stereoisomers of β,γ-CHCH3-dGTP (10, 11) are observed in the ternary complex. The carbon atoms of the (R)-isomer (10) are gray while those of the (S)-isomer (11) are yellow.