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. 2010 Jun 24;6(6):e1001002. doi: 10.1371/journal.pgen.1001002

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Long et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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In SBCS (A) and CGEMS (B). Top panel: Results (-log₁₀P) are shown for the associations of breast cancer risk with directly genotyped (diamonds) and imputed (circles) SNPs located in the TOX3 and LOC643714 genes. P-values for rs4784227 are shown in red for Stage I data and in blue for the combined data. The three previously-reported SNPs (rs8051542, rs12443621, and rs3803662) are highlighted in black. Middle panel: Genomic view at 16q12.1. Gene locations are from the March 2006 UCSC genome browser assembly. Bottom panel: Estimates of pairwise LD (r²) for common SNPs (with MAF≥5%) from HapMap release 23a in the region from 10 kb downstream of rs8051542 to 10 kb upstream of rs4784227.