Table 5. Association of rs4784227 and the three previously-reported SNPs at 16q12with breast cancer risk among European American women.
| Tested SNP a | Study | SNPs Adjusted | No of cases | No of controls | Frequencyb | OR (95% CI) | P for trend |
| rs4784227 | CGEMS | None | 1145 | 1142 | 0.29/0.25 | 1.17(1.03–1.34) | 0.016 |
| NBHS | None | 1357 | 1148 | 0.28/0.25 | 1.21(1.07–1.37) | 0.003 | |
| rs3803662 | CGEMS | None | 1145 | 1142 | 0.3/0.27 | 1.13(0.99–1.28) | 0.06 |
| NBHS | None | 1615 | 1467 | 0.31/0.27 | 1.22(1.09–1.36) | 4.0×10−4 | |
| rs8051542 | NBHS | None | 1587 | 1439 | 0.46/0.44 | 1.07(0.97–1.19) | 0.18 |
| rs12443621 | CGEMS | None | 1145 | 1142 | 0.50/0.49 | 1.02(0.91–1.15) | 0.70 |
| rs4784227 | NBHS | rs8051542 | 1263 | 1080 | 0.28/0.25 | 1.22(1.06–1.40) | 0.007 |
| rs4784227 | CGEMS | rs12443621 | 1145 | 1142 | 0.29/0.25 | 1.25(1.06–1.47) | 0.007 |
| rs4784227 | Both | rs3803662 | 2431 | 2243 | 0.29/0.25 | 1.22(0.94–1.59) | 0.13 |
| rs8051542 | NBHS | rs4784227 | 1263 | 1080 | 0.45/0.44 | 0.98(0.86–1.11) | 0.74 |
| rs12443621 | CGEMS | rs4784227 | 1145 | 1142 | 0.50/0.49 | 0.91(0.79–1.05) | 0.19 |
| rs3803662 | Both | rs4784227 | 2431 | 2243 | 0.31/0.27 | 0.97(0.75–1.25) | 0.82 |
a In CGEMS, data on rs8051542 was not available, and In NBHS data on for rs12443621 was not available.
b Risk allele frequency in cases/controls. Risk/reference alleles (based on forward strand) are T/C for rs8051542 and rs4784227 and A/G for rs12443621 and rs3803662.