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Egr-1 expression in the late lesions of LDLR–/– mice fed a cholesterol-rich diet. LDLR–/– mice sacrificed at 20 weeks, were stained with Egr-1 antibodies. Regions containing raised atherosclerotic lesions are shown in (a) and (b) with Egr-1–positive cells producing a red reaction product (Fast Red) against the light-blue/green counterstain (methylene green).
