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. 2010 Jun 24;6(6):e1000963. doi: 10.1371/journal.ppat.1000963

Table 1. Summary of primary screening results.

Tests C57/BL6 Balb/c Swiss webster
RBC PbA Pch RBC PbA RBC PyNXL Py XL
3D 6D 3D 6D 3D 6D 3D 6D 3D 6D 3D 6D 3D 6D 3D 6D
Reflex and sensory function
Visual placing 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3)
Pinna reflex 1 (1/2) 1 (1/2) 1 (1/2) 1 (0/2) 2 (1/2) 1.25 (1/2) 1 (1/2) 1 (1/2) 1 (1/2) 1 (0/2) 1 (1.2/2) 1 (1/1) 1 (1/1) 1 (0/2) 1 (11/1 1 (0/1)
Toe pinch 3 (3/3) 3 (1/3) 3 (1/3) 3 (1/3) 3 (2/3) 3 (1/3) 3 (2/3) 3 (1/3) 3 (3/3) 2 (3/3) 3 (3/3) 3 (1/3) 3 (2/3) 3 (2/3) 3 (0/3) 3 (0/3)
Corneal reflex 1 (1/2) 1 (1/2) 1 (1/2) 1 (0/2) 1 (1/2) 1 (1/2) 2 (1/2) 1.6 (1/2) 1 (1/2) 1 (0/2) 1.4 (1/2) 1.8 (1/2) 1 (1/2) 1.8 (1/2) 2 (1/2) 1 (1/2)
Contact reflex 1 (1/1) 1 (1/1) 1 (1/1) 1 (0/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (0/1) 1 (1/1) 1 (0/1)
Positional reflex 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0)
Neuropsychiatric state
Spontaneous activity 2 (2/3) 2 (223) 2 (2/2) 2 (1/2) * 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (1/2) 2 (1/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/3) 1 (0/2) *
Transfer arousal 3 (3/5) 3 (3/5) 3 (3/5) 3 (2/5) * 5 (3/5) 4 (3/5) 3 (3/5) 3 (3/5) 3 (3/3) 3 (2/5) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/4) 3 (3/3) 3 (1/3)
Touch escape 3 (2/3) 3 (1/3) 3 (2/3) 3 (1/3) 3 (3/3) 3 (3/3) 3 (2/3) 2 (1/3) 2.5 (2/3) 2 (1/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (1/3)
Positional passivity 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/1)
Fear 1 (0/1) 1 (0/1) 1 (0/1) 1 (0/1) 1 (0/1) 0.5 (0/1) 1 (0/1) 1 (0/1) 1 (0/1) 1 (0/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1)
Biting 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0)
Irritability 1 (1/1) 1 (1/1) 1 (1/1) 1 (0/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1)
Vocals 1 (1/1) 1 (1/1) 1 (1/1) 1 (0/1) * 1 (1/1) 1 (1/1) 1 (0/1) 1 (0/1) 1 (0/1) 1 (0/1) 1 (0/1) 0 (0/1) 0 (0/0) 1 (0/1) 0 (0/0) 1 (0/1) *
Motor behavior
Locomotor activity 17.6 (5.7) 18.0 (6.1) 16.3 (4.9) 14.2 (4.6) * 17.6 (6.5) 21.3 (6.4) 16.1 (5.3) 19.9 (11.2) 11.6 (4.7) 6.5 (4.5) * 13.9 (9.0) 11.8 (5.5) 13.6 (5.2) 9.2 (4.6) 10.2 (6.0) 4.7 (3.8) *
Body position 3 (3/3) 3 (3/3) 3 (3/3) 3 (2/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (3/3) 3 (2/3)
Shivering 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/1) * 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/1) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0)
Gait 0 (0/0) 0 (0/0) 0 (0/0) 1 (0/1) * 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/1) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/1) 0 (0/1) 0.8 (0/3) *
Pelvic elevation 2 (2/2) 2 (2/2) 2 (2/2) 2 (0/3) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (1/2) 2 (2/2) 2 (2/2) 2 (2/3) 2 (2/2) 2 (0/3)
Tail elevation 1 (1/2) 1 (1/2) 1 (1/1) 1 (1/2) * 1 (0/2) 1 (1/2) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/2) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/2) 1 (1/1) 1 (0/1)
Trunk curl 1 (1/1) 1 (1/1) 1 (1/1) 1 (0/1) 1 (1/1) 1 (0/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (0/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 0 (0/1) 0 (0/1) *
Limb grasping 0 (0/0) 0 (0/1) 0 (0/1) 0 (0/1) 0 (0/0) 0.5 (0/1) 0 (0/0) 0 (0/1) 0 (0/0) 0 (0/1) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/1)
Wire manoeuvre 0 (0/1) 0 (0/1) 1 (0/1) 1 (0/3) * 0 (001) 0 (0/0) 0 (0/1) 0 (0/0) 0 (0/0) 0 (0/1) 0 (0/0) 0 (0/0) 0 (0/1) 0.8 (0/1) 0 (0/1) 1 (0/3) *
Negative geotaxis 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/2)
Autonomous function (early CM parameter)
Respiration rate 2 (2/2) 2 (2/2) 2 (2/2) 2 (0/2) * 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (0/2) 0 (0/2) * 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (0/3) 0 (0/2) *
Palpebral closure 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/1) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/1)
Ruffled fur 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/1) * 0 (0/0) 0 (0/0.12) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/1) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/1) 0 (0/0) 0 (0/1) *
Skin color 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 0 (0/1) *
Heart rate 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (0/1)
Tears 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0)
Salivation 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0) 0 (0/0)
Muscle tone and strength (early CM parameter)
Grip strength 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2) 2 (2/2)
Body tone 1 (1/1) 1 (1/1) 1 (1/1) 1 (0/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (0/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (0/1)
Limb tone 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (0/1)
Abdominal tone 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (1/1) 1 (0/1)

Values of individual parameters of Cerebral Malaria (CM) at days 3 and 6 post-infection are shown. Animals infected with malarial parasite (PbA, Pch, PyNXL and PyXL) were compared to animals of the same background inoculated with uninfected RBC. Data are shown as median (upper/lower quartile) or mean ± SD when appropriated. N = 12–15/group.

*p<0.05 or less by Wilcoxon Signed Rank Test.