Skip to main content
. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Neurosci Biobehav Rev. 2009 Nov 13;35(2):157–171. doi: 10.1016/j.neubiorev.2009.11.009

Figure 2.

Figure 2

Ventral tegmental area (VTA) injections of BDNF or GDNF potentiate cue-induced cocaine seeking after withdrawal from the drug. Data are mean±SEM responses per 2 h on the previously active lever during extinction tests for cue-induced cocaine-seeking that were performed on withdrawal days 3 and 10. During the test sessions, cocaine was not available and lever presses resulted in the delivery of the tone-light cue previously paired with cocaine injections. Vehicle, BDNF or GDNF was injected bilaterally into the VTA 1-2 h after the last training session. (A) Timeline of the experiment, (B-C) VTA vehicle, BDNF, or GDNF injections. * Different from Vehicle condition, p< 0.05. SA, self-administration. Data were redrawn from Lu et al. (2004a; 2009).