Table 7.

Proteins identified as Nrf2 dependent in two or more analyses.

SwissProt acc. no.	Protein name	iTRAQ Analysis 1		iTRAQ Analysis 2		2DE gel analysis
Fold-change	p	Fold-change	p	Fold-change	p
Q8VCW8	Acyl-CoA synthetase family member 2, mitochondrial	0.83	0.030	0.86	0.132
P31786	Acyl-CoA-binding protein	1.26	0.073	1.18	0.207
Q91VA0	Acyl-coenzyme A synthetase ACSM1, mitochondrial	0.78	0.039	0.81	0.001
Q9JII6	Alcohol dehydrogenase [NADP+]	0.90	0.121	0.85	0.003
P24549	Aldehyde dehydrogenase family 1, subfamily A1	0.76	0.127	0.72	0.021	0.78	0.003
P16460	Argininosuccinate synthase	1.26	0.162	1.25	0.038
Q91X77	Cytochrome P450 2C50	0.65	0.162	0.58	0.001
Q05816	Fatty acid-binding protein, epidermal	2.97	0.009	1.79	0.005
Q9QXD6	Fructose-1,6-bisphosphatase 1	1.14	0.144	1.18	0.117
P30115	Glutathione S-transferase, alpha 3			0.70	0.001	0.80	0.010
P10649	Glutathione S-transferase, mu 1	0.42	0.009	0.44	0.001	0.60	0.016
P19157	Glutathione S-transferase, pi 1	0.55	0.011	0.62	0.001	0.55	0.009
Q8VCC2	Liver carboxylesterase 1	0.58	0.042	0.56	0.001
P06151	L-lactate dehydrogenase A chain	1.18	0.178	1.20	0.086
Q8VBT2	L-serine dehydratase	1.51	0.078	1.34	0.183
P02762	Major urinary protein 6	0.35	0.057			0.36	0.001
Q99P30	Peroxisomal coenzyme A diphosphatase NUDT7	1.43	0.044	1.13	0.039
Q61207	Sulfated glycoprotein 1	1.22	0.121	1.21	0.057
O70475	UDP-glucose 6-dehydrogenase	0.81	0.061	0.73	0.183
P17717	UDP-glucuronosyltransferase 2B5	0.55	0.004	0.55	0.001

Each protein was significantly (p < 0.05, Student t-test) over- or underexpressed in Nrf2^(−/−) mice compared with the wild type controls in at least two out of the three independent. Fold changes are the ratios of the mean expression changes from 4 to 6 mice.