Table 2.
Neuroimaging differences by AGTR1 and AGTR2 genotypes
| AGTR1 | A/A (N = 135) | C allele carrier (N = 96) | df | Test statistic | p value | |
|---|---|---|---|---|---|---|
| WML, BL | 5.0 (7.7) | 6.9 (11.6) | 153 | 1.40 | 0.1638 | |
| WML, Y2 | 6.0 (9.5) | 9.2 (13.8) | 157 | 1.96 | 0.0523 | |
| WML, change | 0.9 (2.3) | 2.2 (3.9) | 142 | 2.89 | 0.0044 | |
| AGTR2: MEN | C allele (N = 33) | A allele (N = 43) | df | Test statistic | p value | |
| WML, BL | 5.0 (3.7) | 7.1 (13.0) | 50.8 | 1.00 | 0.3201 | |
| WML, Y2 | 5.6 (4.8) | 9.0 (16.6) | 50.9 | 1.28 | 0.2078 | |
| WML, change | 0.6 (2.3) | 1.9 (4.1) | 68.9 | 1.76 | 0.0823 | |
| AGTR2: WOMEN | C/C (N=47) | A/C (N=61) | A/A (N=47) | df | Test statistic | p value |
| WML, BL | 3.7 (1.7) | 6.3 (12.3) | 6.8 (9.1) | 2,154 | 1.58 | 0.2085 |
| WML, Y2 | 5.2 (4.1) | 7.6 (13.5) | 8.5 (11.8) | 2,154 | 1.14 | 0.3238 |
| WML, change | 1.6 (2.9) | 1.4 (2.8) | 1.6 (3.3) | 2,154 | 0.13 | 0.8821 |
Lesion volumes presented in milliliters as mean (SD) and analyzed used the Satterthwaite t-test due unequal variances for the AGTR1 analyses and the AGTR2 analyses in men. ANCOVA was used for AGTR2 analyses in women as genotype was 3-tiered.