Table 2.
Baseline Demographic, Medical and Psychiatric Characteristics of Study Patients (N = 115)
| ALL N = 115 |
Modafinil N = 62 |
Placebo N = 53 |
t or X2 | p | |
|---|---|---|---|---|---|
| Demographic | |||||
| Age, mean (SD) range | 46 (9) 24–70 | 46 (9) | 46 (9) | −0.119 | .906 |
| Ethnicity, number (%) | |||||
| Black | 45 (39%) | 23 (37%) | 22 (42%) | ||
| White (non-Hispanic) | 39 (34%) | 23 (37%) | 16 (30%) | 0.613 | .894 |
| Hispanic | 29 (25%) | 15 (24%) | 14 (26%) | ||
| Other | 2 (2%) | 1 (2%) | 1 (2%) | ||
| Gender, number (%) | |||||
| Men | 100 (87%) | 54 (87%) | 46 (87%) | 0.002 | .961 |
| Women | 15 (13%) | 8 (13%) | 7 (13%) | ||
| Years Education, mean (SD) | 14 (3) | 14 (3) | 14 (3) | 0.384 | .702 |
| Work Status, number (%) | |||||
| Full time | 14 (12%) | 10 (16%) | 4 (8%) | ||
| Part time | 19 (17%) | 12 (19%) | 7 (13%) | 3.252 | .197 |
| Unemployed | 82 (71%) | 40 (65%) | 42 (79%) | ||
| Men who have sex with men, number (%) | 83 (72%) | 45 (73%) | 38 (72%) | 0.011 | .916 |
| Psychiatric | |||||
| DSM-IV depression diagnosis1, number, (%) | 48 (42%) | 27 (44%) | 21 (40%) | 0.181 | .670 |
| Past drug use history, number, (%) | 57 (50%) | 33 (53%) | 24 (45%) | 0.721 | .396 |
| Ham-D2 adjusted for fatigue, mean (SD) | 7 (4) | 8 (4) | 7 (5) | −0.979 | .330 |
| BDI-II3 adjusted for fatigue, mean (SD) | 17 (9) | 17 (9) | 16 (9) | −1.014 | .313 |
| Fatigue Severity Scale, mean (SD) | 52 (6) | 52 (6) | 52 (7) | −0.170 | .865 |
| Chalder Fatigue Scale, mean (SD) | 32 (5) | 32 (5) | 32 (5) | −0.250 | .803 |
| Epworth Sleepiness Scale, mean (SD) | 14 (5) | 14 (5) | 14 (5) | −0.240 | .810 |
| Asymptomatic neurocognitive impairment4 | 80 (78%) | 45 (76%) | 35 (80%) | 0.156 | .690 |
| Medical | |||||
| Months since testing HIV+, mean (SD) | 140 (70) | 134 (69) | 148 (70) | 1.040 | .301 |
| AIDS Diagnosis, number, (%) | 71 (62%) | 39 (63%) | 32 (60%) | 0.077 | .781 |
| Taking antiretroviral therapy, number, (%) | 102 (89%) | 55 (89%) | 47 (89%) | <.001 | .996 |
| Hepatitis C, number, (%) | 22 (19%) | 11 (18%) | 11 (21%) | 0.168 | .682 |
| CD4 cell count, mean (SD) | 471 (254) | 486 (250) | 449 (261) | −0.724 | .470 |
| Log10 Viral Load, mean (SD) | 2.46 (1.16) | 2.50 (1.15) | 2.41 (1.19) | −0.406 | .686 |
1
DSM-IV depression diagnosis of major depressive disorder in partial remission, minor depression, or dysthymia
2
Hamilton Rating Scale for Depression
3
Beck Depression Inventory-II
4
Neurpsychological tests were completed by 103 subjects, 59 in the modafinil group and 44 in the placebo group