Table 3.

Non-Syndromic CHD Resulting from Single Gene Defects

Cardiac Anomalies	Gene
ASD, atrioventricular conduction delay, TOF, tricuspid valve abnormalities	NKX2.5
ASD, VSD	GATA4
ASD, hypertrophic cardiomyopathy	MYH6
Cardiac septation defects associated with PHTN	BMPR2
Endocardial cushion defects	CRELD1, ALK2
BAV, early valve calcification	NOTCH1
d-TGA	PROSIT-240

ASD, atrial septal defect; TOF, tetralogy of Fallot; VSD, ventricular septal defect; TGA, transposition of the great arteries; BAV, bicuspid aortic valve; PHTN, pulmonary hypertension