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. Author manuscript; available in PMC: 2010 Jun 25.
Published in final edited form as: Nat Rev Neurol. 2010 Mar 16;6(4):211–220. doi: 10.1038/nrneurol.2010.18

Figure 3.

Figure 3

TDP-43 histopathology. Immunohistochemistry with an anti-TDP-43 antibody reveals robust staining of ubiquitinated inclusions (brown staining). TDP-43 pathology in FTLD-TDP can be classified into four subtypes, three of which are shown here in frontal cortex tissue: a | type 1 pathology, b | type 2 pathology and c,d | type 3 pathology. e,f | Immunostaining showing TDP-43 inclusions (arrowheads) and nuclear clearance (arrows) in neurons in the hippocampal dentate gyrus. Other morphologies of TDP-43-immunoreactive histopathology include g | intranuclear inclusions, h | lentiform inclusions, and i | round inclusions in motor neurons of the spinal cord. Abbreviations; FTLD-TDP, frontotemporal lobar degeneration with TDP-43 inclusions; TDP-43, TAR DNA-binding protein 43. Reprinted with permission from AAAS © Neumann, M. et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314, 130–133 (2006).