Table 4.
Top quantitative trait (QT) loci ranked by the total number of associations at the significance level of p<10−6. Relevant information about top ranked SNPs and their respective genes (i.e., the closet gene, as annotated in Illumina's Human610-Quad SNP list (except APOE information extracted from dbSNP)) is shown in this table, including SNP, chromosome (CHR), coordinate (Build 36.2), gene, location, and position. In addition, the number of QTs that are associated with each SNP at the significance level of p<10−6 is also shown. The SNPs are ordered according to the last column.
| SNP | CHR | Coordinate | Gene | Location | Position | Number of QT associations | ||
|---|---|---|---|---|---|---|---|---|
| VBM | FreeSurfer | Total | ||||||
| rs10932886 | 2 | 221428332 | EPHA4 | Flanking_3UTR | −562,659 | 27 | 0 | 27 |
| rs429358 | 19 | 50103781 | APOE | Coding | Exon 4 | 4 | 15 | 19 |
| rs7610017 | 3 | 190826118 | TP63 | Flanking_5UTR | −5792 | 19 | 0 | 19 |
| rs6463843 | 7 | 8805242 | NXPH1 | Flanking_3UTR | −46124 | 9 | 0 | 9 |
| rs2075650 | 19 | 50087459 | TOMM40 | Intron | −31 | 0 | 5 | 5 |
| rs16912145 | 10 | 59752674 | UBE2D1 | Flanking_5UTR | −12071 | 4 | 0 | 4 |
| rs12531488 | 7 | 144523019 | LOC643308 | Flanking_5UTR | −154052 | 3 | 0 | 3 |
| rs7526034 | 1 | 63359561 | LOC199897 | Flanking_5UTR | −103696 | 0 | 2 | 2 |
| rs7647307 | 3 | 69705878 | LOC642487 | Flanking_5UTR | −31337 | 0 | 2 | 2 |
| rs4692256 | 4 | 27353816 | LOC391642 | Flanking_3UTR | −156945 | 1 | 0 | 1 |