Table 2.
Kidney disease in pTg18R mice
| pTg18R diseaseda | IgG a-chrb | IgGc | IgMc | C3c | H&E staind |
|---|---|---|---|---|---|
| 1 | + | 1-2,M | 1,M | 0 | 0 |
| 2 | + | 0 | 1-2, M | 0 | 2, p, m |
| 3 | + | 3, M | 2-3, M,P | 3, M | 2, p, m, LI |
| 4 | + | 0 | 0 | 0 | 0 |
| 5 | − | 2, P | 3,P | 3, P | 2, p, m, LI |
| 6 | − | 0 | 1,M | 0 | 0 |
| 7 | + | 1-2, P | 2-3, M, P | 2, P | 3, p, m |
| 8 | − | 0 | 2,M | 2, M | 0 |
| 9 | + | 2, P, gbm | 0 | 1, P, gbm | 3, p, m |
| 10 | + | 1-2, M | 2, M | 1, M | 0 |
|
| |||||
| SWR | |||||
|
| |||||
| 1 | − | 0 | 1,M | 0 | 0 |
| 2 | − | 0 | 0 | 0 | 0 |
| 3 | − | 0 | 1,M | 0 | 0 |
| 4 | − | 0 | 2,M | 0 | 0 |
| 5 | − | 0 | 1,M | 0 | 0 |
| 6 | − | 0 | 0 | 0 | 0 |
| 7 | − | 0 | 0 | 0 | 0 |
| 8 | − | 0 | 0 | 0 | Nd |
| 9 | − | 0 | 0 | 0 | Nd |
| 10 | − | 0 | 0 | 0 | Nd |
These mice exhibited at least one of the 3 following signs of disease: IgG anti-chromatin, skin lesions or splenomegaly.
IgG anti-chromatin detected in sera.
Kidney sections were analyzed by immunofluorescence for IgG, IgM and C3 deposition. “M” indicates mesangial staining, “P” indicates peripheral capillary loop staining, “gbm” indicates staining clearly associated with glomerular basement membrane.
Kidney sections analyzed in an H&E stain. “p” indicates peripheral involvement, “m” indicates mesangial involvement and “LI” indicates inflammatory cellular infiltrates including macrophages, lymphocytes and neutrophils. “Nd” indicates not analyzed by H&E stain.
Numbers indicate pathologic index where 0 is no disease and 4 is most severe.