Table 1.
Baseline characteristics of hemodialysis patients in the HEMO Study
| Characteristics | Cohort without CVD or stroke mortality event (n=1436) | Cohort with CVD mortality event (n=292) | Cohort with stroke mortality event (n=62) | P† |
|---|---|---|---|---|
| Age (mean±SD years) | 56±14 | 63±11 | 61±14 | <0.0001 |
| Female sex (%) | 57 | 56 | 63 | 0.60 |
| Black race (%) | 64 | 56 | 69 | 0.02 |
| Serum albumin (mean±SD gm/dL)* | 3.9±0.3 | 3.8±0.3 | 3.8±0.3 | 0.07 |
| Total cholesterol (mean±SD mg/dL)** | 172±40 | 178±44 | 176±42 | 0.09 |
| Index of Coexisting Disease (ICED) scores | <0.0001 | |||
| none (%) | 0 | 0 | 0 | |
| mild (%) | 39 | 23 | 28 | |
| moderate (%) | 31 | 35 | 24 | |
| severe (%) | 30 | 42 | 48 | |
| Index of Disease Severity (IDS) score | ||||
| Arrhythmia and conduction problems | <0.0001 | |||
| none (%) | 72 | 57 | 53 | |
| mild (%) | 18 | 26 | 32 | |
| moderate (%) | 7 | 13 | 10 | |
| severe (%) | 3 | 4 | 5 | |
| Congestive heart failure | <0.0001 | |||
| none (%) | 64 | 45 | 52 | |
| mild (%) | 26 | 37 | 30 | |
| moderate (%) | 8 | 16 | 16 | |
| severe (%) | 2 | 2 | 2 | |
| Cerebral and peripheral vascular diseases | <0.0001 | |||
| none (%) | 67 | 50 | 52 | |
| mild (%) | 18 | 23 | 24 | |
| moderate (%) | 11 | 15 | 14 | |
| severe (%) | 4 | 12 | 10 | |
| Cerebral vascular disease | <0.0001 | |||
| none (%) | 83 | 71 | 73 | |
| mild (%) | 4 | 8 | 5 | |
| moderate (%) | 12 | 20 | 19 | |
| severe (%) | 1 | 1 | 3 | |
| Ischemic and other heart disease | <0.0001 | |||
| none (%) | 31 | 13 | 19 | |
| mild (%) | 62 | 72 | 68 | |
| moderate (%) | 6 | 14 | 8 | |
| severe (%) | 1 | 1 | 5 | |
| Respiratory disease | 0.06 | |||
| none (%) | 86 | 81 | 76 | |
| mild (%) | 7 | 11 | 14 | |
| moderate (%) | 6 | 7 | 10 | |
| severe (%) | 1 | 1 | 0 | |
| Malignancy (%) | 5 | 8 | 7 | 0.04 |
| Nonvascular nervous system disease | 0.20 | |||
| none (%) | 64 | 58 | 60 | |
| mild (%) | 18 | 21 | 22 | |
| moderate (%) | 18 | 20 | 18 | |
| severe (%) | 0 | 1 | 0 | |
| Gastrointestinal and hepatobiliary disease | 0.18 | |||
| none (%) | 55 | 49 | 42 | |
| mild (%) | 20 | 22 | 24 | |
| moderate (%) | 21 | 24 | 26 | |
| severe (%) | 4 | 5 | 8 | |
| High Kt/V group (%) | 50 | 50 | 44 | 0.60 |
| High flux group (%) | 51 | 46 | 45 | 0.20 |
†
ANOVA was used to test differences among means for the continuous variables; Fisher’s exact test was used to compare frequency data among groups for ICED and IDS scores for cerebral vascular disease, ischemic and other heart disease, respiratory disease, and nonvascular nervous system disease; Chi-square test was used to compare all other frequency data among groups; P < 0.05 was considered statistically significant
*
n=1009 for group with no CVD or stroke mortality, n=175 for group with CVD mortality, n=43 for group with stroke mortality
**
n=1287 for group with no CVD or stroke mortality, n=277 for group with CVD mortality, n=60 for group with stroke mortality