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. Author manuscript; available in PMC: 2011 Jun 7.
Published in final edited form as: Mol Pharm. 2010 Jun 7;7(3):884–893. doi: 10.1021/mp100029t

Figure 3. Distribution time course of intranasal delivery to the brain.

Figure 3

At 800 nm an anesthetized rat is relatively transparent using an Odyssey infrared imaging system (A). At 0 minutes after the first 1mM drop was delivered it was clearly seen at an 800 nm wavelength (B). At 5 minutes the IRdye can be clearly seen in the nasal cavity (C). At 10 minutes IRdye 800 enters the olfactory bulb (D). At 15 minutes IRdye 800 enters the cortex (E). There were no significant changes in IRdye 800 distribution between 15, 20 and 25 minutes. Every 2 minutes an 8μL drop was administered.