Table 2.

Inhibition of HSV-1 Entry into Mammalian Cells by Size-fractionated Carboxylated Lignins CD and FD.^a

Fractions	IC50	IC50b	HC
	(ng/mL)	(nM)
FD3	72±1c	13.6±0.2	1.1±0.1
FD5	127±4	13.1±0.4	1.0±0.1
FD10	111±2	8.4±0.2	1.0±0.1
FD30	284±12	17.3±0.4	1.2±0.1
CD3	153±7	28.9±1.4	0.5±0.1
CD5	269±21	50.8±4.0	0.5±0.1
CD10	295±14	55.7±2.7	0.6±0.1
CD30	220±8	17.2±0.6	0.8±0.2

^aThe IC₅₀ values are concentrations of carboxylated lignins that result in 50% reduction in level of HSV-1 entry. IC₅₀ and HC values were obtained through non-linear regression analysis of viral entry data in the presence and absence of carboxylated lignins (see ‘Experimental Methods’).

^bCalculated using M_W values from Table 1.

^cErrors represent ± 2 S. E.